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We hope that you will find NRx informative. If you have feedback or questions, please contact www uhnresearch. The risk of falling is influenced by age-related differences in maneuvering stairs.

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Skip to search form Skip to main content. Nazareno Published DOI: Adult plant resistance of Thatcher wheat to stem rust.

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Physical Interaction report. Jump to Gene Search FlyBase. Open Close.

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Neurexin-1 regulates sleep and synaptic plasticity in Drosophila melanogaster. Eur J Neurosci [Epub ahead of print]. PubMed ID: Summary : Neurexins are cell adhesion molecules important for synaptic plasticity and homeostasis, though links to sleep have not yet been investigated.

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Study record managers: refer to the Data Element Definitions if submitting registration or results information. In recent years, intravenous and intranasal ketamine have demonstrated rapid and potent effects in achieving remission from both depression and suicidal ideation in both bipolar depression and major depressive disorder. However ketamine is will understood to induce hallucination and other dissociative side effects, to be addictive and have high abuse potential, and to have potential neurotoxic effects.

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Rapastinel GLYX is an investigational intravenous formulation of a novel NMDA receptor partial agonist, which is being evaluated for adjunctive treatment of MDD, and has shown a rapid onset of antidepressant efficacy 1 day after a single dose in a Phase 2 clinical trial of patients with MDD who had an inadequate response to one or more antidepressants. No psychotomimetic or hallucinogenic side effects were observed with rapastinel. A series of Phase 3 registration trials are planned to begin in

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Building arborisations of the right size and shape is fundamental for neural network function. Live imaging in vertebrate brains strongly suggests that nascent synapses are critical for branch growth during development. The molecular mechanisms underlying this are largely unknown.

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SF 54 for the U. Makes any warranty or representation, expressed or implied, with respect to the accuracy, completeness, or usefulness of the in- formation contained in this report, or that the use of any information, apparatus, method, or process disclosed in this report may not in- fringe privately owned rights; or B. Assumes any liabilities with respect to the use of, or for damages 'resulting from the use of any information, apparatus, method, or pro- cess disclosed in this report. As used in the above, "person acting on behalf of the Commission" in- cludes any employee or contractor of the Commission, or employee of such contractor, to the extent that such employee or contractor of the Commission, or employee of such contractor prepares, dissemin- ates, or provides access to, any information pursuant to his employ- ment or contract with the Commission, or his employment with such contractor.

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Nucleoredoxin NRX is a member of the thioredoxin family of proteins that controls redox homeostasis in cell. Redox homeostasis is a well-known regulator of cell differentiation into various tissue types. Knockdown of NRX decreased differentiation of 3T3-L1 cells, whereas overexpression increased differentiation.

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Neurexins Nrxs have emerged as potential determinants of synaptic specificity, but little is known about their localization at central synapses. Here we show that Nrxs have a remarkably selective localization at distinct types of glutamatergic synapses and we reveal an unexpected ontogenetic regulation of Nrx expression at GABAergic synapses. Our data indicate that synapses are specified by molecular interactions that involve both Nrx-dependent and Nrx-independent mechanisms.


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